About: Multi-subtype Natural Human Leukocyte Interferon Alpha     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Multi-subtype Natural Human Leukocyte Interferon Alpha
rdfs:subClassOf
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Pharmacologic Substance
Preferred_Name
  • Multi-subtype Natural Human Leukocyte Interferon Alpha
NCI_META_CUI
  • CL430253
PDQ_Open_Trial_Search_ID
  • 703644
PDQ_Closed_Trial_Search_ID
  • 703644
FULL_SYN
  • Multisubtype Natural Human Interferon AlphaSYNCI
  • Multi-subtype Natural Human Leukocyte Interferon AlphaPTNCI
  • MultiferonBRNCI
DEFINITION
  • A preparation containing a mixture of multiple naturally occurring, active subtypes 1, 2, 8, 10, 14 and 21 of interferon alpha (IFN-alpha) with immunomodulating, anti-viral and anti-cancer activities. Multi-subtype natural human leukocyte IFN-alpha is purified from the leukocyte fraction of human blood challenged with Sendai virus. Upon administration, IFN-alpha subtypes bind to cell surface IFN-alpha receptors (IFNARs), resulting in an upregulation of interferon stimulated genes and related protein products. This ultimately leads to the proliferation of human B cells, activation of natural killer (NK) cells and dendritic cells (DCs), an increase in HLA-I and HLA-II expression and activation of CD8-lymphocytes. Compared to single-subtype IFN, multi-subtypes act synergistically.NCI
code
  • C97509
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