About: Paclitaxel Ceribate

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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Paclitaxel Ceribate
rdfs:subClassOf	Taxane Compound Taxane-Pocket Binding Agent nodeID://b701476 nodeID://b701477 nodeID://b701478 nodeID://b701479 nodeID://b701480
Has_Target	Tubulin
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Organic Chemical Pharmacologic Substance
Preferred_Name	Paclitaxel Ceribate
NCI_META_CUI	CL429502
CAS_Registry	186040-50-6
FDA_UNII_Code	B3C86E80A0
Contributing_Source	FDA
Chemical_Formula	C51H57NO18
FULL_SYN	7beta-((2RS)-2,3-dihydroxypropoxycarbonyloxy)-1-hydroxy-9-oxo-5beta,20-epoxytax-11-ene-2alpha,4,10beta,13alpha-tetrayl 4,10-diacetate 2-benzoate 13-((2R,3S)-3-benzamido-2-hydroxy-3-phenylpropanoate)SNNCI Paclitaxel CeribatePTNCI PACLITAXEL CERIBATEPTFDAB3C86E80A0
DEFINITION	The ceribate ester form of paclitaxel, a compound extracted from the Pacific yew tree Taxus brevifolia with antineoplastic activity. Paclitaxel binds to and stabilizes tubulin thereby inhibiting the disassembly of microtubules, resulting in the inhibition of cell division. This agent also induces apoptosis by binding to and blocking the function of the apoptosis inhibitor protein B-cell Leukemia 2 (BCL2).NCI
code	C96934

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