About: Amsacrine Lactate     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Amsacrine Lactate
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Amsacrine Lactate
NSC_Code
  • 141549
UMLS_CUI
  • C1271552
CAS_Registry
  • 80277-11-8
FDA_UNII_Code
  • 959PWE0Q2E
Contributing_Source
  • FDA
Chemical_Formula
  • C21H19N3O3S.C3H6O3
FULL_SYN
  • m-AMSA lactateSYNCI
  • N-(4-(9-Acridinylamino)-3-methoxyphenyl)methanesulfonamide compd. with Lactic AcidSNNCI
  • Methanesulfon-m-anisidide, 4'-(9-acridinylamino)-, compd. with Lactic AcidSNNCI
  • Amsacrine LactatePTNCI
  • AMSACRINE LACTATEPTFDA959PWE0Q2E
DEFINITION
  • The lactate form of amsacrine, an aminoacridine analog and topoisomerase II inhibitor, with antineoplastic activity. Although the exact relationship between DNA binding and its activity has yet to be fully elucidated, amsacrine intercalates DNA through its acridine moiety, and its nonintercalative headgroup impedes topoisomerase II activity, augmenting enzyme-mediated DNA cleavage and resulting in DNA double-strand breaks. This ultimately induces programmed cell death.NCI
code
  • C96771
is Has_Salt_Form of
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