About: Amsacrine

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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Amsacrine
rdfs:subClassOf	DNA Intercalating Agent
Has_Salt_Form	Amsacrine Lactate
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Organic Chemical Pharmacologic Substance
Preferred_Name	Amsacrine
NSC_Code	249992
UMLS_CUI	C0591085
CAS_Registry	51264-14-3
In_Clinical_Trial_For	Myeloid leukemia
FDA_UNII_Code	00DPD30SOY
Contributing_Source	FDA
PDQ_Open_Trial_Search_ID	39142
PDQ_Closed_Trial_Search_ID	39142
Chemical_Formula	C21H19N3O3S
Legacy_Concept_Name	Amsacrine
CHEBI_ID	CHEBI:2687
FULL_SYN	m-AMSASYDTPNSC0249992 Cain's AcridineSYNCI SN 11841SYDTPNSC0156303 AMSAABNCI 4'-(9-Acridinylamino)methane-sulfon-m-anisidideSNNCI AmsidineSYDTPNSC0249992 CI-880CNNCI m-AMSAABNCI AMSACRINEPTFDA00DPD30SOY N-[4-(9-Acridinylamino)-3-methoxyphenyl]methanesulfonamideSNNCI AmekrinFBNCI AmsidylFBNCI AmsacrineSYDTPNSC0249992 SN-11841CNNCI SN-21429CNNCI Amsa P-DBRNCI Acridinyl AnisidideSYNCI LamasineFBNCI AmsidineFBNCI AmsacrinePTNCI amsacrinePTNCI-GLOSSCDR0000045172
DEFINITION	An aminoacridine derivative with potential antineoplastic activity. Although its mechanism of action is incompletely defined, amsacrine may intercalate into DNA and inhibit topoisomerase II, resulting in DNA double-strand breaks, arrest of the S/G2 phase of the cell cycle, and cell death. This agent's cytotoxicity is maximal during the S phase of the cell cycle when topoisomerase levels are greatest. In addition, amsacrine may induce transcription of tumor promoter p53 protein and block p53 ubiquitination and proteasomal degradation, resulting in p53-dependent tumor cell apoptosis.NCI
code	C240
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0001042
is someValuesFrom of	nodeID://b645579 nodeID://b645584 nodeID://b645588 nodeID://b645590 nodeID://b645593 nodeID://b645595 nodeID://b645598 nodeID://b645601 nodeID://b645606 nodeID://b645607 nodeID://b645610
is Has_Free_Acid_Or_Base_Form of	Amsacrine Lactate

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