About: G-Quadruplex Stabilizer BMVC

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About: G-Quadruplex Stabilizer BMVC Goto Sponge NotDistinct Permalink

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Attributes	Values
rdf:type	Class
rdfs:label	G-Quadruplex Stabilizer BMVC
rdfs:subClassOf	DNA Binding Agent
Semantic_Type	Pharmacologic Substance
Preferred_Name	G-Quadruplex Stabilizer BMVC
NCI_META_CUI	CL428290
PDQ_Open_Trial_Search_ID	696431
PDQ_Closed_Trial_Search_ID	696431
FULL_SYN	3,6-bis[2-(1-methylpyridinium)vinyl]carbazole DiiodideSNNCI 3,6-bis (1-methyl-4-vinylpyridinium) Carbazole DiiodideSNNCI BMVCABNCI G-Quadruplex Stabilizer BMVCPTNCI
DEFINITION	A carbazole derivative (3,6-bis[2-(1-methylpyridinium)vinyl]carbazole diiodide) that selectively targets to the G-quadruplex DNA structure, used as a fluorescent probe for cancer cytological diagnosis and with potential antitumor activity. G-quadruplex stabilizer BMVC, preferentially uptaken by cancer cells, binds to and stabilize the telomeric G-quadruplex structure at the end of DNA; when visualized with fluorescent imaging device, BMVC emits bright fluorescent light and can be used to differentiate tumor cells from normal cells. The BMVC/G-quadruplex complexes also interfere with the activity of telomerase, which is highly active in tumor cells and plays a key role in tumorigenesis while expressed at very low levels in most somatic cells.NCI
code	C95893

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