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AttributesValues
rdf:type
rdfs:label
  • DNA Binding Agent
rdfs:subClassOf
Semantic_Type
  • Chemical Viewed Functionally
Preferred_Name
  • DNA Binding Agent
UMLS_CUI
  • C1511661
Legacy_Concept_Name
  • DNA_Binding_Agent
FULL_SYN
  • DNA Binding AgentPTNCI
DEFINITION
  • DNA binding molecules regulate mechanisms central to cellular function, including DNA replication and gene expression. Many small molecules that mimic or block these processes offer potential therapeutic agents. Understanding how complexation affects both the structural and mechanical properties of DNA is an important step towards understanding the functional mechanisms of binding agents, and may also provide a key to more rational drug design. There are three major classes of binding modes: intercalation, groove binding and covalent crosslinking.NCI
code
  • C2842
is rdfs:subClassOf of
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