About: Selumetinib Sulfate

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Attributes	Values
rdf:type	Class
rdfs:label	Selumetinib Sulfate
rdfs:subClassOf	Mitogen-Activated Protein Kinase Kinase Inhibitor nodeID://b711866 nodeID://b711867 nodeID://b711868
Has_Free_Acid_Or_Base_Form	Selumetinib
Has_Target	Mitogen-Activated Protein Kinase Kinase Kinase 1
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Pharmacologic Substance
Preferred_Name	Selumetinib Sulfate
UMLS_CUI	C2987007
CAS_Registry	943332-08-9
FDA_UNII_Code	807ME4B7IJ
Contributing_Source	FDA
Chemical_Formula	C17H15BrClFN4O3.H2O4S
FULL_SYN	AZD6244 Hydrogen SulfateCNNCI 5-((4-Bromo-2-Chlorophenyl)amino)-4-Fluoro-N-(2-Hydroxyethoxy)-1-Methyl-1H- Benzimidazole-6-Carboxamide SulfateSNNCI AZD-6244 Hydrogen SulfateCNNCI AZD6244 Hydrogen SulphateCNNCI 5-((4-Bromo-2-Chlorophenyl)amino)-4-Fluoro-N-(2-Hydroxyethoxy)-1-Methyl-1H- Benzimidazole-6-Carboxamide SulphateSNNCI 1H-Benzimidazole-6-Carboxamide, 5-((4-Bromo-2-Chlorophenyl)Amino)-4-Fluoro-N-(2- Hydroxyethoxy)-1-Methyl-, Sulfate (1:1)SNNCI 1h-Benzimidazole-6-Carboxamide,5-((4-Bromo-2-Chlorophenyl)Amino)-4-Fluoro-N-(2- Hydroxyethoxy)-1-Methyl-, Sulphate (1:1)SNNCI Selumetinib SulfatePTNCI SELUMETINIB SULFATEPTFDA807ME4B7IJ Selumetinib SulphateSYNCI
DEFINITION	The sulfate salt of selumetinib, an orally active, small molecule with potential antineoplastic activity. Selumetinib is an ATP-independent inhibitor of mitogen-activated protein kinase kinase (MEK or MAPK/ERK kinase) 1 and 2. MEK 1 and 2 are dual specificity kinases that are essential mediators in the activation of the RAS/RAF/MEK/ERK pathway, are often upregulated in various cancer cells, and are drivers of diverse cellular responses, including proliferation. Inhibition of both MEK1 and 2 by selumetinib prevents the activation of MEK1/2 dependent effector proteins and transcription factors, thereby leading to an inhibition of cellular proliferation in various cancers.NCI
code	C95225
is Has_Salt_Form of	Selumetinib

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