About: Selumetinib     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Selumetinib
rdfs:subClassOf
Has_Salt_Form
Has_Target
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Selumetinib
UMLS_CUI
  • C1832054
CAS_Registry
  • 606143-52-6
In_Clinical_Trial_For
  • Non-Small Cell Lung Cancer; Melanoma; Pancreatic Cancer
FDA_UNII_Code
  • 6UH91I579U
Contributing_Source
  • FDA
ALT_DEFINITION
  • A substance being studied in the treatment of several types of cancer. AZD6244 blocks proteins needed for cell growth and may kill cancer cells. It is a type of protein kinase inhibitor.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 532294
PDQ_Closed_Trial_Search_ID
  • 532294
Chemical_Formula
  • C17H15BrClFN4O3
Legacy_Concept_Name
  • AZD6244
FULL_SYN
  • ARRY-142886CNNCI
  • SelumetinibPTNCI
  • MEK inhibitor AZD6244PTNCI-GLOSSCDR0000600473
  • AZD6244PTNCI-GLOSSCDR0000600474
  • AZD6244CNNCI
  • SELUMETINIBPTFDA6UH91I579U
  • MEK Inhibitor AZD6244SYNCI
DEFINITION
  • An orally active, small molecule with potential antineoplastic activity. Selumetinib is an ATP-independent inhibitor of mitogen-activated protein kinase kinase (MEK or MAPK/ERK kinase) 1 and 2. MEK 1 and 2 are dual specificity kinases that are essential mediators in the activation of the RAS/RAF/MEK/ERK pathway, are often upregulated in various cancer cells, and are drivers of diverse cellular responses, including proliferation. Inhibition of both MEK1 and 2 by selumetinib prevents the activation of MEK1/2 dependent effector proteins and transcription factors, thereby leading to an inhibition of cellular proliferation in various cancers.NCI
code
  • C66939
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