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AttributesValues
rdf:type
rdfs:label
  • Vosaroxin
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Vosaroxin
PubMedID_Primary_Reference
  • 20233886
UMLS_CUI
  • C1451341
CAS_Registry
  • 175414-77-4
FDA_UNII_Code
  • K6A90IIZ19
Contributing_Source
  • FDA
Chemical_Formula
  • C18H19N5O4S
FULL_SYN
  • 1,4-Dihydro-7-(3-methoxy-4-methylamino-1-pyrrolidinyl)-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acidSNNCI
  • VOSAROXINPTFDAK6A90IIZ19
  • AG-7352CNNCI
  • SPC 595CNNCI
  • SNS-595CNNCI
  • VoreloxinSYNCI
  • VosaroxinPTNCI
DEFINITION
  • A small molecule and a naphthyridine analogue with antineoplastic activity. Vosaroxin intercalates into DNA in a site-specific manner and blocks the re-ligation process carried out by topoisomerase II during DNA replication. As a result, inhibition of DNA replication, RNA and protein synthesis occurs, followed by cell cycle arrest at G2 phase and induced p53-independent apoptosis. This agent shows a favorable toxicity profile in several aspects: it does not generate reactive oxygen species, as do anthracyclines, hence reducing the risk of cardiotoxicity; it is not a P-glycoprotein (P-gp) substrate, and thereby evades the common mechanism for multidrug resistance; and it has limited distribution to normal tissues and a more chemically stable molecular structure.NCI
code
  • C95148
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