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AttributesValues
rdf:type
rdfs:label
  • Warfarin
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Warfarin
NSC_Code
  • 59813
UMLS_CUI
  • C0043031
CAS_Registry
  • 81-81-2
Accepted_Therapeutic_Use_For
  • Pulmonary embolism and thromboembolic disorders, treatment and prophylaxis; Venous thrombosis, prophylaxis and treatment
In_Clinical_Trial_For
  • Chemotherapy-induced INR changes; Thrombosis prophylaxis
FDA_UNII_Code
  • 5Q7ZVV76EI
Contributing_Source
  • FDA
ALT_DEFINITION
  • A drug that prevents blood from clotting. It belongs to the family of drugs called anticoagulants (blood thinners).NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 39740
PDQ_Closed_Trial_Search_ID
  • 39740
Chemical_Formula
  • C19H16O4
Legacy_Concept_Name
  • Warfarin
CHEBI_ID
  • CHEBI:10033
FULL_SYN
  • Compound 42BRNCI
  • Athrombin-KBRNCI
  • 4-Hydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-oneSNNCI
  • 3-(.alpha.-Phenyl-.beta.-acetylethyl)-4-hydroxycoumarinSYDTPNSC0059813
  • WARF Compound 42BRNCI
  • WARFARINPTFDA5Q7ZVV76EI
  • 1-(4'-Hydroxy-3'-coumarinyl)-1-phenyl-3-butanoneSNNCI
  • RodexBRNCI
  • WARF compound 42SYDTPNSC0059813
  • WarfarinSYDTPNSC0059813
  • Co-RaxBRNCI
  • 3-(.alpha.-Acetonylbenzyl)-4-hydroxycoumarinSYDTPNSC0059813
  • 3-Alpha-phenyl-beta-acetylethyl-4-hydroxycoumarinSNNCI
  • warfarinPTNCI-GLOSSCDR0000045249
  • WarfarinPTNCI
  • Compound 42SYDTPNSC0059813
  • 3-(Alpha-acetonylbenzyl)-4-hydroxycoumarinSNNCI
DEFINITION
  • A synthetic anticoagulant. Warfarin inhibits the regeneration of vitamin K1 epoxide and so the synthesis of vitamin K dependent clotting factors, which include Factors II, VII, IX and X, and the anticoagulant proteins C and S. This inhibition results in a sequential depression of Factors VII, IX, X and II activities. Vitamin K is an essential cofactor for the post ribosomal synthesis of the vitamin K dependent clotting factors. The vitamin promotes the biosynthesis of gamma-carboxyglutamic acid residues in these proteins which are essential for biological activity.NCI
code
  • C945
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