About: Pixantrone Dimaleate     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Pixantrone Dimaleate
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Pixantrone Dimaleate
NCI_META_CUI
  • CL408667
CAS_Registry
  • 144675-97-8
Accepted_Therapeutic_Use_For
  • non-Hodgkin's lyphoma
FDA_UNII_Code
  • P0R64C4CR9
Contributing_Source
  • FDA
ALT_DEFINITION
  • A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called antitumor antibiotics.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 269678
PDQ_Closed_Trial_Search_ID
  • 269678
Chemical_Formula
  • C17H19N5O2.2C4H4O4
Legacy_Concept_Name
  • Pixantrone_Dimaleate
FULL_SYN
  • PIXANTRONE DIMALEATEPTFDAP0R64C4CR9
  • Benz(g)Isoquinoline-5,10-Dione, 6,9-Bis((2-Aminoethyl)Amino)-, (2z)-2-Butenedioate (1:2)SNNCI
  • Benz(g)isoquinoline-5,10-dione, 6,9-bis((2-aminoethyl)amino)-, (2Z)-2-butenedioate (1:2)SNNCI
  • BBR 2778PTNCI-GLOSSCDR0000322132
  • Pixantrone MaleateSYNCI
  • BBR 2778CNNCI
  • 6,9-Bis((2-Aminoethyl)Amino)Benzo(g)Isoquinoline-5,10-Dione (2z)-But-2-Enedioate (1:2)SNNCI
  • Pixantrone DimaleatePTNCI
DEFINITION
  • The dimaleate salt of a synthetic, noncardiotoxic aza-anthracenedione analogue with potential antineoplastic activity. Pixantrone intercalates into DNA and induces topoisomerase II-mediated DNA strand crosslinks, resulting in inhibition of DNA replication and tumor cell cytotoxicity.NCI
code
  • C82398
is Has_Salt_Form of
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