About: Folate Receptor-Targeted Vinca Alkaloid EC0489     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Folate Receptor-Targeted Vinca Alkaloid EC0489
rdfs:subClassOf
Has_Target
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Folate Receptor-Targeted Vinca Alkaloid EC0489
UMLS_CUI
  • C2830054
PDQ_Open_Trial_Search_ID
  • 638649
PDQ_Closed_Trial_Search_ID
  • 638649
Legacy_Concept_Name
  • Folate_Receptor_Targeted-Microtubule_Destabilizing_Agent_EC0489
FULL_SYN
  • Folate Receptor-Targeted Vinca Alkaloid EC0489PTNCI
  • EC0489CNNCI
DEFINITION
  • A folate receptor-targeting cytotoxic drug conjugate consisting of a folate vitamin analogue linked to a vinca alkaloid microtubule destabilizing agent with potential antineoplastic activity. Mediated through its folate moiety, folate receptor-targeted vinca alkaloid EC0489 delivers the cytotoxic vinca alkaloid moiety directly to cells expressing folic acid receptors, frequently upregulated in many types of tumor cells. After ligand-receptor internalization, the vinca alkaloid moiety binds to tubulin and disrupts microtubule assembly-disassembly dynamics, resulting in cell cycle arrest and apoptosis. The relative tumor cell specificity of this agent reduces the toxicity profile of its vinca alkaloid moiety.NCI
code
  • C81935
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