About: Ceftriaxone Sodium     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Ceftriaxone Sodium
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Antibiotic
  • Organic Chemical
Preferred_Name
  • Ceftriaxone Sodium
UMLS_CUI
  • C0035750
CAS_Registry
  • 104376-79-6
FDA_UNII_Code
  • 023Z5BR09K
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 41088
PDQ_Closed_Trial_Search_ID
  • 41088
Chemical_Formula
  • 2C18H16N8O7S3.4Na.7H2O
Legacy_Concept_Name
  • Ceftriaxone
FULL_SYN
  • Ceftriaxone SodiumPTNCI
  • CEFTRIAXONE SODIUMPTFDA023Z5BR09K
  • RocephinBRNCI
DEFINITION
  • The sodium salt form of ceftriaxone, a beta-lactam, third-generation cephalosporin antibiotic with bactericidal activity. Ceftriaxone binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. PBPs participate in the terminal stages of assembling the bacterial cell wall, and in reshaping the cell wall during cell division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis. Compared to the second and first generation cephalosporins, ceftriaxone is more active against gram-negative bacteria and less active against gram-positive bacteria. Ceftriaxone also crosses the blood-brain barrier and reaches therapeutic concentrations in the central nervous system (CNS).NCI
code
  • C817
sameAs
http://linked.open...y/mesh/hasConcept
is someValuesFrom of
is Has_Salt_Form of
is sameAs of
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