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AttributesValues
rdf:type
rdfs:label
  • Sotrastaurin Acetate
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Sotrastaurin Acetate
UMLS_CUI
  • C2830197
CAS_Registry
  • 908351-31-5
FDA_UNII_Code
  • R1SIA15KZ1
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 708113
PDQ_Closed_Trial_Search_ID
  • 708113
Chemical_Formula
  • C25H22N6O2.C2H4O2
Legacy_Concept_Name
  • Sotrastaurin_Acetate
FULL_SYN
  • SOTRASTAURIN ACETATEPTFDAR1SIA15KZ1
  • AEB071CNNCI
  • 3-(1H-Indol-3-yl)-4-(2-(4-methylpiperazin-1-yl)quinazolin-4- yl)-1H-pyrrole-2,5-dione AcetateSNNCI
  • AEB 071CNNCI
  • Sotrastaurin AcetatePTNCI
DEFINITION
  • The acetate salt form of sotrastaurin, an orally available pan-protein kinase C (PKC) inhibitor with potential immunosuppressive and antineoplastic activities. Sotrastaurin inhibits both T- and B-cell activations via PKC theta and beta isozymes, respectively. Both PKCs are important in the activation of nuclear factor-kappaB (NF-kB). Inhibition of PKC beta in B-cells results in prevention of NF-kB-mediated signaling and down regulation of NF-kB target genes. This may eventually lead to an induction of G1 cell cycle arrest and tumor cell apoptosis in susceptible tumor cells. This agent may act synergistically with other chemotherapeutic agents. PKC, a family of serine/threonine protein kinases overexpressed in certain types of cancer cells, is involved in cell differentiation, mitogenesis, inflammation, and the activation and survival of lymphocytes.NCI
code
  • C80631
is Has_Salt_Form of
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