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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Sotrastaurin
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Sotrastaurin
UMLS_CUI
  • C2742796
CAS_Registry
  • 425637-18-9
FDA_UNII_Code
  • 7I279E1NZ8
Contributing_Source
  • FDA
Chemical_Formula
  • C25H22N6O2
Legacy_Concept_Name
  • Sotrastaurin
FULL_SYN
  • SOTRASTAURINPTFDA7I279E1NZ8
  • SotrastaurinPTNCI
DEFINITION
  • An orally available pan-protein kinase C (PKC) inhibitor with potential immunosuppressive and antineoplastic activities. Sotrastaurin inhibits both T- and B-cell activations via PKC theta and beta isozymes, respectively. Both PKCs are important in the activation of nuclear factor-kappaB (NF-kB). Inhibition of PKC beta in B-cells results in prevention of NF-kB-mediated signaling and down regulation of NF-kB target genes. This may eventually lead to an induction of G1 cell cycle arrest and tumor cell apoptosis in susceptible tumor cells. This agent may act synergistically with other chemotherapeutic agents. PKC, a family of serine/threonine protein kinases overexpressed in certain types of cancer cells, is involved in cell differentiation, mitogenesis, inflammation, and the activation and survival of lymphocytes.NCI
code
  • C80630
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