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AttributesValues
rdf:type
rdfs:label
  • Dinaciclib
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Dinaciclib
UMLS_CUI
  • C2698720
CAS_Registry
  • 779353-01-4
FDA_UNII_Code
  • 4V8ECV0NBQ
Contributing_Source
  • FDA
ALT_DEFINITION
  • A substance being studied in the treatment of advanced melanoma (a type of skin cancer) and other types of cancer. It blocks cell division and may cause cancer cells to die. It is a type of cyclin-dependent kinase inhibitor.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 612855
PDQ_Closed_Trial_Search_ID
  • 612855
Chemical_Formula
  • C21H28N6O2
Legacy_Concept_Name
  • CDK_Inhibitor_SCH_727965
FULL_SYN
  • 2-Piperidineethanol, 1-[3-ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5- a]pyrimidin-5-yl]-, (2S)-SNNCI
  • dinaciclibPTNCI-GLOSSCDR0000662958
  • CDK Inhibitor SCH 727965SYNCI
  • DINACICLIBPTFDA4V8ECV0NBQ
  • CDK inhibitor SCH 727965PTNCI-GLOSSCDR0000662959
  • SCH 727965CNNCI
  • DinaciclibPTNCI
DEFINITION
  • A pyrazolo[1,5-a]pyrimidine with potential antineoplastic activity. Dinaciclib selectively inhibits cyclin dependent kinases CDK1, CDK2, CDK5, and CDK9; inhibition of CDK1 and CDK2 may result in cell cycle repression and tumor cell apoptosis.NCI
code
  • C78854
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