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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Piroxicam
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Piroxicam
NSC_Code
  • 666076
UMLS_CUI
  • C0031990
CAS_Registry
  • 36322-90-4
FDA_UNII_Code
  • 13T4O6VMAM
Contributing_Source
  • FDA
ALT_DEFINITION
  • A cyclooxygenase inhibiting, non-steroidal anti-inflammatory agent (NSAID) that is well established in treating rheumatoid arthritis and osteoarthritis and used for musculoskeletal disorders, dysmenorrhea, and postoperative pain. Its long half-life enables it to be administered once daily.MSH2002_06_01
PDQ_Open_Trial_Search_ID
  • 39761
PDQ_Closed_Trial_Search_ID
  • 39761
Chemical_Formula
  • C15H13N3O4S
Legacy_Concept_Name
  • Piroxicam
CHEBI_ID
  • CHEBI:8249
FULL_SYN
  • 4-Hydroxy-2-methyl-N-2-pyridinyl-2H-1,2-benzothiazine-3-carboximide-1,1-dioxideSNNCI
  • PiroxicamPTDCP00355
  • PXMABNCI
  • PIROXICAMPTFDA13T4O6VMAM
  • FeldeneBRNCI
  • PiroxicamSYDTPNSC0666076
  • PiroxicamPTNCI
DEFINITION
  • A nonsteroidal oxicam derivative with anti-inflammatory, antipyretic and analgesic properties. As a non-selective, nonsteroidal anti-inflammatory drug (NSAID), piroxicam binds and chelates both isoforms of cyclooxygenases (COX1 and COX2), thereby stalling phospholipase A2 activity and conversion of arachidonic acid into prostaglandin precursors at the rate limiting cyclooxygenase enzyme step. This results in inhibition of prostaglandin biosynthesis. As a second, independent effect, piroxicam inhibits the activation of neutrophils thereby contributing to its overall anti-inflammatory effects.NCI
code
  • C751
sameAs
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