About: Aminopterin Sodium

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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Aminopterin Sodium
rdfs:subClassOf	Dihydrofolate Reductase Inhibitor Folate Antagonist
Has_Free_Acid_Or_Base_Form	Aminopterin
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Amino Acid, Peptide, or Protein Pharmacologic Substance
Preferred_Name	Aminopterin Sodium
UMLS_CUI	C0282048
CAS_Registry	58602-66-7
FDA_UNII_Code	FZU1QI13O9
Contributing_Source	FDA
Chemical_Formula	C19H18N8O5.2Na
Legacy_Concept_Name	Aminopterin_Sodium
FULL_SYN	Sodium AminopterinSYNCI Aminopterin SodiumPTNCI Aminopterin SodiumSYNCI AMINOPTERIN SODIUMPTFDAFZU1QI13O9
DEFINITION	The sodium salt of a pterin derivative with antineoplastic and immunosuppressive properties. As a folate analogue, aminopterin competes for the folate binding site of the enzyme dihydrofolate reductase, thereby blocking tetrahydrofolate synthesis, and resulting in depletion of nucleotide precursors and inhibition of DNA, RNA and protein synthesis. (NCI04)NCI
code	C74554
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0331223
is Has_Salt_Form of	Aminopterin

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