About: Apricoxib     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Apricoxib
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Apricoxib
UMLS_CUI
  • C1737955
CAS_Registry
  • 197904-84-0
FDA_UNII_Code
  • 5X5HB3VZ3Z
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 594363
PDQ_Closed_Trial_Search_ID
  • 594363
Chemical_Formula
  • C19H20N2O3S
Legacy_Concept_Name
  • COX-2_Inhibitor_TG01
FULL_SYN
  • TG01CNNCI
  • CS-706CNNCI
  • TP2001CNNCI
  • APRICOXIBPTFDA5X5HB3VZ3Z
  • R-109339CNNCI
  • COX-2 Inhibitor TG01SYNCI
  • ApricoxibPTNCI
DEFINITION
  • An orally bioavailable nonsteroidal anti-inflammatory agent (NSAID) with potential antiangiogenic and antineoplastic activities. Apricoxib binds to and inhibits the enzyme cyclooxygenase-2 (COX-2), thereby inhibiting the conversion of arachidonic acid into prostaglandins. Apricoxib-mediated inhibition of COX-2 may induce tumor cell apoptosis and inhibit tumor cell proliferation and tumor angiogenesis. COX-related metabolic pathways may represent crucial regulators of cellular proliferation and angiogenesis.NCI
code
  • C74021
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