About: Amotosalen Hydrochloride     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Amotosalen Hydrochloride
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Amotosalen Hydrochloride
UMLS_CUI
  • C2346748
CAS_Registry
  • 161262-45-9
FDA_UNII_Code
  • 67B255SI5F
Contributing_Source
  • FDA
Chemical_Formula
  • C17H19NO4.ClH
Legacy_Concept_Name
  • Amotosalen_Hydrochloride
FULL_SYN
  • Amotosalen HydrochloridePTNCI
  • AMOTOSALEN HYDROCHLORIDEPTFDA67B255SI5F
DEFINITION
  • The hydrochloride salt form of amotosalen, a synthetic psoralen and light-activated DNA, RNA crosslinking agent, with protective activity against pathogens such as bacteria, viruses, protozoa, and leukocytes. Prior to administration amotosalen is added to plasma and platelets, then in vivo the agent penetrates pathogens and targets DNA and RNA. Upon activation by ultraviolet A light, this agent is able to form interstrand DNA and RNA crosslinks and prevents replication. Inactivation of leukocytes can prevent graft versus host disease upon transfusion.NCI
code
  • C72699
is Has_Salt_Form of
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