About: KSP Inhibitor ARRY-520     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • KSP Inhibitor ARRY-520
rdfs:subClassOf
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • KSP Inhibitor ARRY-520
UMLS_CUI
  • C2346611
PDQ_Open_Trial_Search_ID
  • 546990
PDQ_Closed_Trial_Search_ID
  • 546990
Legacy_Concept_Name
  • KSP_Inhibitor_ARRY-520
FULL_SYN
  • ARRY-520CNNCI
  • KSP Inhibitor ARRY-520PTNCI
DEFINITION
  • A synthetic, small molecule targeting the kinesin spindle protein (KSP) with potential antineoplastic activity. KSP inhibitor ARRY-520 specifically inhibits KSP (kinesin-5 or Eg5), resulting in activation of the spindle assembly checkpoint, induction of cell cycle arrest during the mitotic phase, and consequently cell death in tumor cells that are actively dividing. Because KSP is not involved in postmitotic processes, such as neuronal transport, this agent does not cause the peripheral neuropathy that is often associated with tubulin-targeting agents. KSP is an ATP-dependent microtubule motor protein that is essential for the formation of bipolar spindles and the proper segregation of sister chromatids during mitosis.NCI
code
  • C68937
http://linked.open...y/mesh/hasConcept
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