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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Nafoxidine
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Nafoxidine
UMLS_CUI
  • C0027328
CAS_Registry
  • 1845-11-0
FDA_UNII_Code
  • 4RIY10WM82
Contributing_Source
  • FDA
Chemical_Formula
  • C29H31NO2
Legacy_Concept_Name
  • Nafoxidine
FULL_SYN
  • NFXABNCI
  • NAFOXIDINEPTFDA4RIY10WM82
  • NafoxidinePTNCI
DEFINITION
  • A triphenylethylene nonsteroidal agent that acts as a partial estrogen antagonist. Nafoxidine competes with endogenous estrogen for binding to specific estrogen receptors. This agent also inhibits angiogenesis in some tissues by blocking the effects of fibroblast growth factor (FGF) and vascular endothelial growth factor (VEGF); paradoxically, it may enhance angiogenesis in uterine tissue. Nafoxidine also induces oxidative stress, protein kinase C and calcium signaling. (NCI04)NCI
code
  • C677
sameAs
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