About: Nafoxidine Hydrochloride     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Nafoxidine Hydrochloride
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Nafoxidine Hydrochloride
NSC_Code
  • 70735
UMLS_CUI
  • C0919376
CAS_Registry
  • 1847-63-8
FDA_UNII_Code
  • SU8WBD61G1
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 39309
PDQ_Closed_Trial_Search_ID
  • 39309
Chemical_Formula
  • C29H31NO2.HCl
Legacy_Concept_Name
  • Nafoxidine_Hydrochloride
FULL_SYN
  • 1-[2-[4-(3,4-Dihydro-6-methoxy-2-phenyl-1-naphthalenyl)phenoxy]ethyl]pyrrolidine HydrochloridePTDCP05813
  • Nafoxidine HydrochloridePTNCI
  • NAFOXIDINE HYDROCHLORIDEPTFDASU8WBD61G1
  • U 11100ACNNCI
  • U-11,000ACNNCI
  • 1-[2-[4-(3,4-Dihydro-6-methoxy-2-phenyl-1-naphthalenyl)phenoxy]ethyl]pyrrolidine HydrochlorideSNNCI
DEFINITION
  • The hydrochloride salt of the partial estrogen antagonist nafoxidine. Nafoxidine competes with endogenous estrogen for binding to specific estrogen receptors. This agent also inhibits angiogenesis in some tissues by blocking the effects of fibroblast growth factor (FGF) and vascular endothelial growth factor (VEGF); paradoxically, it may enhance angiogenesis in uterine tissue. Nafoxidine also induces oxidative stress, protein kinase C and calcium signaling. (NCI04)NCI
code
  • C1448
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