About: Gemcitabine     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Gemcitabine
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Nucleic Acid, Nucleoside, or Nucleotide
Preferred_Name
  • Gemcitabine
UMLS_CUI
  • C0045093
CAS_Registry
  • 95058-81-4
FDA_UNII_Code
  • B76N6SBZ8R
Contributing_Source
  • FDA
ALT_DEFINITION
  • The active ingredient in a drug that is used to treat pancreatic cancer that is advanced or has spread. It is also used with other drugs to treat breast cancer that has spread, advanced ovarian cancer, and non-small cell lung cancer that is advanced or has spread. It is also being studied in the treatment of other types of cancer. Gemcitabine blocks the cell from making DNA and may kill cancer cells. It is a type of antimetabolite.NCI-GLOSS
Chemical_Formula
  • C9H11F2N3O4
Legacy_Concept_Name
  • Gemcitabine_Base
CHEBI_ID
  • CHEBI:175901
FULL_SYN
  • DifluorodeoxycytidineSYNCI
  • GemcitabineSYDTPNSC0613327
  • GemcitabinePTNCI
  • gemcitabinePTNCI-GLOSSCDR0000045347
  • dFdCABNCI
  • dFdCydABNCI
  • 2'Deoxy-2',2'-DifluorocytidineSNNCI
  • GEMCITABINEPTFDAB76N6SBZ8R
  • 1-(2-Oxo-4-amino-1,2-dihydropyrimidin-1-yl)-2-deoxy-2,2-difluororiboseSNNCI
DEFINITION
  • A broad-spectrum antimetabolite and deoxycytidine analogue with antineoplastic activity. Upon administration, gemcitabine is converted into the active metabolites difluorodeoxycytidine diphosphate (dFdCDP) and difluorodeoxycytidine triphosphate (dFdCTP) by deoxycytidine kinase. dFdCTP competes with deoxycytidine triphosphate (dCTP) and is incorporated into DNA. This locks DNA polymerase thereby resulting in "masked termination" during DNA replication. On the other hand, dFdCDP inhibits ribonucleotide reductase, thereby decreasing the deoxynucleotide pool available for DNA synthesis. The reduction in the intracellular concentration of dCTP potentiates the incorporation of dFdCTP into DNA.NCI
code
  • C66876
sameAs
http://linked.open...y/mesh/hasConcept
is Has_Free_Acid_Or_Base_Form of
is sameAs of
Faceted Search & Find service v1.16.118 as of Jun 21 2024


Alternative Linked Data Documents: ODE     Content Formats:   [cxml] [csv]     RDF   [text] [turtle] [ld+json] [rdf+json] [rdf+xml]     ODATA   [atom+xml] [odata+json]     Microdata   [microdata+json] [html]    About   
This material is Open Knowledge   W3C Semantic Web Technology [RDF Data] Valid XHTML + RDFa
OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 58 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software