About: Gemcitabine     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Gemcitabine
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Nucleic Acid, Nucleoside, or Nucleotide
Preferred_Name
  • Gemcitabine
UMLS_CUI
  • C0045093
CAS_Registry
  • 95058-81-4
FDA_UNII_Code
  • B76N6SBZ8R
Contributing_Source
  • FDA
ALT_DEFINITION
  • The active ingredient in a drug that is used to treat pancreatic cancer that is advanced or has spread. It is also used with other drugs to treat breast cancer that has spread, advanced ovarian cancer, and non-small cell lung cancer that is advanced or has spread. It is also being studied in the treatment of other types of cancer. Gemcitabine blocks the cell from making DNA and may kill cancer cells. It is a type of antimetabolite.NCI-GLOSS
Chemical_Formula
  • C9H11F2N3O4
Legacy_Concept_Name
  • Gemcitabine_Base
CHEBI_ID
  • CHEBI:175901
FULL_SYN
  • DifluorodeoxycytidineSYNCI
  • GemcitabineSYDTPNSC0613327
  • GemcitabinePTNCI
  • gemcitabinePTNCI-GLOSSCDR0000045347
  • dFdCABNCI
  • dFdCydABNCI
  • 2'Deoxy-2',2'-DifluorocytidineSNNCI
  • GEMCITABINEPTFDAB76N6SBZ8R
  • 1-(2-Oxo-4-amino-1,2-dihydropyrimidin-1-yl)-2-deoxy-2,2-difluororiboseSNNCI
DEFINITION
  • A broad-spectrum antimetabolite and deoxycytidine analogue with antineoplastic activity. Upon administration, gemcitabine is converted into the active metabolites difluorodeoxycytidine diphosphate (dFdCDP) and difluorodeoxycytidine triphosphate (dFdCTP) by deoxycytidine kinase. dFdCTP competes with deoxycytidine triphosphate (dCTP) and is incorporated into DNA. This locks DNA polymerase thereby resulting in "masked termination" during DNA replication. On the other hand, dFdCDP inhibits ribonucleotide reductase, thereby decreasing the deoxynucleotide pool available for DNA synthesis. The reduction in the intracellular concentration of dCTP potentiates the incorporation of dFdCTP into DNA.NCI
code
  • C66876
sameAs
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