About: Mitoxantrone Hydrochloride

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Attributes	Values
rdf:type	Class
rdfs:label	Mitoxantrone Hydrochloride
rdfs:subClassOf	Anthraquinones
Has_Free_Acid_Or_Base_Form	MITOXANTRONE
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Antibiotic Organic Chemical
Preferred_Name	Mitoxantrone Hydrochloride
NSC_Code	301739
UMLS_CUI	C1513359
CAS_Registry	70476-82-3
Accepted_Therapeutic_Use_For	Acute Leukemia; Breast cancer; Non Hodgkins Lymphoma; Multiple sclerosis; Prostate cancer
In_Clinical_Trial_For	Acute leukemia; Adult lymphoblastic lymphoma; AIDS-Related lymphoma; Breast cancer; Chronic myelogenous leukemia; Hodgkins lymphoma; Lymphoblastic lymphoma; Myelodysplastic syndrome; Ovarian epithelial cancer; Prostate cancer
FDA_UNII_Code	U6USW86RD0
Contributing_Source	FDA
ALT_DEFINITION	A drug used to treat advanced prostate cancer that does not respond to hormones, adult acute nonlymphocytic leukemia, and advanced or chronic multiple sclerosis. It is also being studied in the treatment of other cancers. It belongs to the family of drugs called antitumor antibiotics.NCI-GLOSS
PDQ_Open_Trial_Search_ID	39219
PDQ_Closed_Trial_Search_ID	39219
Chemical_Formula	C22H28N4O6.2HCl
Legacy_Concept_Name	Mitoxantrone
CHEBI_ID	CHEBI:50727
FULL_SYN	DHADSYDTPNSC0301739 DHAQSYDTPNSC0279836 NovantronePTNCI-GLOSSCDR0000413952 1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9, 10-anthroquinone DihydrochlorideSNNCI DHADABNCI DHAQABNCI Mitoxantrone HydrochloridePTNCI Mitozantrone HydrochlorideSYNCI 1,3-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9, 10-anthracenedione DihydrochlorideSNNCI Mitoxantroni HydrochloridumSYNCI Mitoxantrone DihydrochlorideSYNCI PralifanFBNCI MITOXANTRONE HYDROCHLORIDEPTFDAU6USW86RD0 NeotalemFBNCI CL 232315CNNCI Dihydroxyanthracenedione DihydrochlorideSYNCI OnkotroneFBNCI MitroxoneFBNCI NovantroneBRNCI
DEFINITION	The hydrochloride salt of an anthracenedione antibiotic with antineoplastic activity. Mitoxantrone intercalates into and crosslinks DNA, thereby disrupting DNA and RNA replication. This agent also binds to topoisomerase II, resulting in DNA strand breaks and inhibition of DNA repair. Mitoxantrone is less cardiotoxic compared to doxorubicin.NCI
code	C665
sameAs	Mitoxantrone Hydrochloride
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0474355
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