About: Mitoxantrone     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Mitoxantrone
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Mitoxantrone
NSC_Code
  • 279836
UMLS_CUI
  • C0026259
CAS_Registry
  • 65271-80-9
FDA_UNII_Code
  • BZ114NVM5P
Contributing_Source
  • FDA
ALT_DEFINITION
  • A drug used to treat advanced prostate cancer that does not respond to hormones, adult acute nonlymphocytic leukemia, and advanced or chronic multiple sclerosis. It is also being studied in the treatment of other cancers. It belongs to the family of drugs called antitumor antibiotics.NCI-GLOSS
Chemical_Formula
  • C22H28N4O6
Legacy_Concept_Name
  • Mitoxantrone_Base
CHEBI_ID
  • CHEBI:50729
FULL_SYN
  • MITOXANTRONEPTFDABZ114NVM5P
  • MitoxantroneSYDTPNSC0301739
  • MitoxantronePTNCI
  • MitozantroneSYNCI
  • 1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9, 10-anthroquinoneSNNCI
  • DihydroxyanthracenedioneSYNCI
  • mitoxantronePTNCI-GLOSSCDR0000045192
  • 1,3-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9, 10-anthracenedioneSNNCI
DEFINITION
  • An anthracenedione antibiotic with antineoplastic activity. Mitoxantrone intercalates into and crosslinks DNA, thereby disrupting DNA and RNA replication. This agent also binds to topoisomerase II, resulting in DNA strand breaks and inhibition of DNA repair. Mitoxantrone is less cardiotoxic compared to doxorubicin.NCI
code
  • C62050
sameAs
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