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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Netilmicin Sulfate
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Netilmicin Sulfate
UMLS_CUI
  • C0700550
CAS_Registry
  • 56391-57-2
FDA_UNII_Code
  • S741ZJS97U
Contributing_Source
  • FDA
Chemical_Formula
  • 2C21H41N5O7.5H2O4S
Legacy_Concept_Name
  • Netilmicin_Sulfate
CHEBI_ID
  • CHEBI:7529
FULL_SYN
  • Netilmicin SulfatePTNCI
  • NETILMICIN SULFATEPTFDAS741ZJS97U
DEFINITION
  • The sulfate salt form of netilimicin, a semisynthetic, water soluble aminoglycoside antibiotic. Netilmicin is derived from sisomicin, a naturally occurring aminoglycoside antibiotic produced by the fermentation of Micromonospora inyoensis. Netilmicin irreversibly binds to the 16S rRNA and S12 protein of the bacterial 30S ribosomal subunit. As a result, this agent interferes with the assembly of initiation complex between mRNA and the bacterial ribosome, thereby inhibiting the initiation of protein synthesis. In addition, netilmicin induces misreading of the mRNA template and causes translational frameshift, thereby results in premature termination. This eventually leads to bacterial cell death.NCI
code
  • C66237
sameAs
http://linked.open...y/mesh/hasConcept
is Has_Salt_Form of
is sameAs of
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