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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Netilmicin
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Netilmicin
UMLS_CUI
  • C0027780
CAS_Registry
  • 56391-56-1
FDA_UNII_Code
  • 4O5J85GJJB
Contributing_Source
  • FDA
Chemical_Formula
  • C21H41N5O7
Legacy_Concept_Name
  • Netilmicin
CHEBI_ID
  • CHEBI:7528
FULL_SYN
  • NETILMICINPTFDA4O5J85GJJB
  • NetilmicinPTNCI
DEFINITION
  • A semisynthetic, water soluble aminoglycoside derived from sisomicin, a naturally occurring antibiotic produced by the fermentation of Micromonospora inyoensis. Netilmicin irreversibly binds to the 16S rRNA and S12 protein of the bacterial 30S ribosomal subunit. As a result, this agent interferes with the assembly of initiation complex between mRNA and the bacterial ribosome, thereby inhibiting the initiation of protein synthesis. In addition, netilmicin induces misreading of the mRNA template and causes translational frameshift, thereby results in premature termination. This eventually leads to bacterial cell death.NCI
code
  • C66236
sameAs
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