About: Fosinopril     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Fosinopril
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Fosinopril
UMLS_CUI
  • C0118168
CAS_Registry
  • 98048-97-6
FDA_UNII_Code
  • R43D2573WO
Contributing_Source
  • FDA
Chemical_Formula
  • C30H46NO7P
Legacy_Concept_Name
  • Fosinopril
CHEBI_ID
  • CHEBI:5163
FULL_SYN
  • FOSINOPRILPTFDAR43D2573WO
  • FosinoprilPTNCI
DEFINITION
  • A phosphinic acid-containing angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. As an ester prodrug, fosinopril is hydrolysed by esterases to its active metabolite fosinoprilat. Fosinoprilat specifically and competitively inhibits angiotensin-converting enzyme thereby decreasing the formation of the potent vasoconstrictor angiotensin II, resulting in diminished vasopressor activity. In addition, angiotensin II-mediated aldosterone secretion by adrenal cortex is decreased, which results in a decrease of sodium retention and an increase in water outflow.NCI
code
  • C65761
sameAs
http://linked.open...y/mesh/hasConcept
is Has_Free_Acid_Or_Base_Form of
is sameAs of
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