About: Fosinopril Sodium     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Fosinopril Sodium
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Fosinopril Sodium
UMLS_CUI
  • C0733440
CAS_Registry
  • 88889-14-9
FDA_UNII_Code
  • NW2RTH6T2N
Contributing_Source
  • FDA
Chemical_Formula
  • C30H45NO7P.Na
Legacy_Concept_Name
  • Fosinopril_Sodium
CHEBI_ID
  • CHEBI:5164
FULL_SYN
  • Fosinopril SodiumPTDCP32057
  • L-proline, 4-Cyclohexyl-1-[[[2-methyl-1-(1-oxopropoxy) propoxyl](4-phenylbutyl) phosphinyl]acetyl]-,Sodium Salt, trans-SNNCI
  • Fosinopril SodiumPTNCI
  • FOSINOPRIL SODIUMPTFDANW2RTH6T2N
  • NewaceFBNCI
  • ElitenSYNCI
  • MonoprilBRNCI
DEFINITION
  • The sodium salt of fosinopril, a phosphinic acid-containing angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. Fosinopril sodium is an ester prodrug that is hydrolysed by esterases to its active metabolite fosinoprilat. Fosinoprilat specifically and competitively inhibits angiotensin-converting enzyme thereby decreasing the formation of the potent vasoconstrictor angiotensin II, resulting in diminished vasopressor activity. In addition, angiotensin II-mediated aldosterone secretion by adrenal cortex is decreased, which results in a decrease of sodium retention and an increase of serum potassium. (NCI05)NCI
code
  • C47542
sameAs
http://linked.open...y/mesh/hasConcept
is Has_Salt_Form of
is sameAs of
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