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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Ebselen
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Ebselen
UMLS_CUI
  • C0058903
CAS_Registry
  • 60940-34-3
FDA_UNII_Code
  • 40X2P7DPGH
Contributing_Source
  • FDA
Chemical_Formula
  • C13H9NOSe
Legacy_Concept_Name
  • Ebselen
FULL_SYN
  • EBSELENPTFDA40X2P7DPGH
  • EbselenPTNCI
DEFINITION
  • A organoselenium compound with anti-inflammatory, anti-oxidant and cytoprotective activity. Ebselen acts as a glutathione peroxidase mimetic and is thereby able to prevent cellular damage induced by reactive oxygen species (ROS). In addition, this agent inhibits the activity of a variety of enzymes including nitric oxide synthase (NOS), 5-lipoxygenase, cyclooxygenase, protein kinase C (PKC), NADPH oxidase and gastric H+/K+-ATPase. Furthermore, ebselen may be neuroprotective due to its ability to neutralize free radicals upon NMDA receptor activation thus, reducing lipoperoxidation mediated by glutamate-induced excitotoxicity.NCI
code
  • C65503
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