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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Metolazone
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Metolazone
UMLS_CUI
  • C0025854
CAS_Registry
  • 17560-51-9
FDA_UNII_Code
  • TZ7V40X7VX
Contributing_Source
  • FDA
ALT_DEFINITION
  • A potent, long acting diuretic useful in chronic renal disease. It also tends to lower blood pressure and increase potassium loss.MSH2002_06_01
Chemical_Formula
  • C16H16ClN3O3S
Legacy_Concept_Name
  • Metolazone
CHEBI_ID
  • CHEBI:64354
FULL_SYN
  • MetolazonePTDCP32079
  • 2-Methyl-3-o-tolyl-6-sulfamyl-7-chloro-1,2,3,4-tetrahydro-4-quinazolinoneSNNCI
  • DiuloBRNCI
  • XuretFBNCI
  • MykroxBRNCI
  • MetenixFBNCI
  • METOLAZONEPTFDATZ7V40X7VX
  • 7-Chloro-1,2,3,4-tetrahydro-2-methyl-4-oxo-3-o-tolyl-6-quinazolinesulfonamideSNNCI
  • SR-720-22CNNCI
  • 7-Chloro-1,2,3,4-tetrahydro-2-methyl-3-(2-methylphenyl)-4-oxo-6-quinazolinesulfonamideSNNCI
  • ZaroxolynBRNCI
  • MetolazonePTNCI
DEFINITION
  • A long acting, quinazoline-based sulfonamide thiazide-like, diuretic. Similar to the thiazides, metolazone acts on the distal convoluted tubule (DCT) and inhibits the sodium-chloride symporter, thereby preventing sodium and chloride reabsorption and excretion of water.NCI
code
  • C650
sameAs
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