About: Thiazide Diuretic

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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Thiazide Diuretic
rdfs:subClassOf	DIURETICS
Semantic_Type	Chemical Viewed Functionally
Preferred_Name	Thiazide Diuretic
UMLS_CUI	C0012802
Legacy_Concept_Name	Thiazide_Diuretic
FULL_SYN	Thiazide DiureticPTNCI
DEFINITION	Any benzothiadiazide derivative or other thiazide-like agent with diuretic and anti-hypertensive activity. Thiazide diuretics inhibit the sodium-chloride transporter in the distal tubule in the kidneys, thereby suppressing sodium and chloride reabsorption from the distal convoluted tubules (DCT) and increasing the excretion of sodium, chloride, potassium and water. In addition, thiazide diuretics decrease excretion of calcium and uric acid. These agents cause vasodilation possibly by activating calcium-activated potassium channels in vascular smooth muscle and inhibiting various carbonic anhydrases in vascular tissue.NCI
code	C49185
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0006628
is rdfs:subClassOf of	METHYCLOTHIAZIDE METOLAZONE Meticrane Paraflutizide Sumetizide Mebutizide CHLOROTHIAZIDE HYDROCHLOROTHIAZIDE INDAPAMIDE Bendroflumethiazide CHLORTHALIDONE HYDROFLUMETHIAZIDE POLYTHIAZIDE TRICHLORMETHIAZIDE BENZTHIAZIDE CHLOROTHIAZIDE SODIUM CYCLOTHIAZIDE Fenquizone QUINETHAZONE Bemetizide Penflutizide Teclothiazide Epithiazide Benzylhydrochlorothiazide Althiazide Cyclopenthiazide Ethiazide Clopamide Hydrobentizide Fenquizone Potassium
is sameAs of	THIAZIDES/RELATED DIURETICS

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