About: Fermented Wheat Germ Extract     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Fermented Wheat Germ Extract
rdfs:subClassOf
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Fermented Wheat Germ Extract
UMLS_CUI
  • C0756278
PDQ_Open_Trial_Search_ID
  • 529839
PDQ_Closed_Trial_Search_ID
  • 529839
Legacy_Concept_Name
  • Fermented_Wheat_Germ_Extract
FULL_SYN
  • FWGEABNCI
  • Fermented Wheat Germ ExtractPTNCI
  • AvemarBRNCI
DEFINITION
  • An extract of fermented wheat germ containing a concentrated, standardized amount of methoxy-substituted benzoquinones with immunomodulatory and potential antineoplastic activities. Fermented wheat germ extract (FWGE) inhibits the activities of several enzymes involved in de novo nucleic acid synthesis and in supplying the dNTP pool required for DNA replication. This agent also induces caspase-3- mediated inactivation of poly(ADP)ribose polymerase (PARP), a key enzyme in DNA repair that is overexpressed in many cancers; cleavage of PARP prevents DNA repair and induces apoptosis. The benzoquinones may contribute to the immunomodulatory effects of FWGE, down-regulating major histocompatibility complex class I (MHC-1) protein on the surface of cancer cells, allowing natural killer (NK) cell surveillance; and up-regulating the expression of intracellular adhesion molecule 1 (ICAM-1) on tumor endothelial cells.NCI
code
  • C64763
http://linked.open...y/mesh/hasConcept
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