About: Crenolanib     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Crenolanib
rdfs:subClassOf
Has_Target
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Crenolanib
UMLS_CUI
  • C1879973
CAS_Registry
  • 670220-88-9
FDA_UNII_Code
  • LQF7I567TQ
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 518325
PDQ_Closed_Trial_Search_ID
  • 518325
Chemical_Formula
  • C26H29N5O2
Legacy_Concept_Name
  • CP-868_596
FULL_SYN
  • PDGFR Inhibitor CP-868596SYNCI
  • [1-[2-[5-(3-Methyloxetan-3-ylmethoxy)benzimidazol-1-yl]quinolin-8-yl]piperidin-4-yl]amineSNNCI
  • ARO-002CNNCI
  • 4-Piperidinamine, 1-[2-[5-[(3-methyl-3-oxetanyl)methoxy]-1Hbenzimidazol-1-yl]-8-quinolinyl]-SNNCI
  • CRENOLANIBPTFDALQF7I567TQ
  • CP-868596CNNCI
  • CP-868,596CNNCI
  • CrenolanibPTNCI
DEFINITION
  • An orally bioavailable small molecule, targeting the platelet-derived growth factor receptor (PDGFR), with potential antineoplastic activity. Crenolanib binds to and inhibits PDGFR, which may result in the inhibition of PDGFR-related signal transduction pathways, and, so, the inhibition of tumor angiogenesis and tumor cell proliferation. PDGFR, up-regulated in many tumor cell types, is a receptor tyrosine kinase essential to cell migration and the development of the microvasculature.NCI
code
  • C64639
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