About: Pegdinetanib

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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Pegdinetanib
rdfs:subClassOf	Tyrosine Kinase Inhibitor nodeID://b655261 nodeID://b655262 nodeID://b655263 nodeID://b655264 nodeID://b655265
Semantic_Type	Pharmacologic Substance
Preferred_Name	Pegdinetanib
UMLS_CUI	C1831965
ALT_DEFINITION	A substance being studied in the treatment of cancer. CT-322 may prevent the growth of new blood vessels that tumors need to grow and may kill cancer cells. It is a type of vascular endothelial growth factor receptor-2 (VEGFR-2) inhibitor and a type of antiangiogenesis agent.NCI-GLOSS
PDQ_Open_Trial_Search_ID	575516
PDQ_Closed_Trial_Search_ID	575516
Legacy_Concept_Name	CT-322
FULL_SYN	PegdinetanibPTNCI CT-322PTNCI-GLOSSCDR0000600470 CT-322CNNCI VEGFR-2 inhibitor CT-322PTNCI-GLOSSCDR0000600471 AngioceptBRNCI BMS-844203CNNCI AngioceptPTNCI-GLOSSCDR0000600472
DEFINITION	A pegylated form of a thermostable and protease resistant peptide targeting human vascular endothelial growth factor receptor-2 (VEGFR-2) with potential antiangiogenic activity. Derived from the 10th type III domain of human fibronectin and one of the natural ligands, pegdinetanib binds to VEGFR-2 and prevents activation of VEGFR-2 by other activating ligands. This may inhibit the growth of new tumor blood vessels.NCI
code	C62791

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