About: Seliciclib

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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Seliciclib
rdfs:subClassOf	Cyclin-Dependent Kinase Inhibitor nodeID://b711857 nodeID://b711858 nodeID://b711859 nodeID://b711860 nodeID://b711861 nodeID://b711862 nodeID://b711863
Has_Target	Cyclin-Dependent Kinases
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Organic Chemical Pharmacologic Substance
Preferred_Name	Seliciclib
UMLS_CUI	C1436187
CAS_Registry	186692-46-6
FDA_UNII_Code	0ES1C2KQ94
Contributing_Source	FDA
PDQ_Open_Trial_Search_ID	511023
PDQ_Closed_Trial_Search_ID	511023
Chemical_Formula	C19H26N6O
Legacy_Concept_Name	Seliciclib
FULL_SYN	R-roscovitineSYNCI CYC202CNNCI SELICICLIBPTFDA0ES1C2KQ94 SeliciclibPTNCI
DEFINITION	An orally available small molecule and cyclin-dependent kinase (CDK) inhibitor with potential apoptotic and antineoplastic activity. CDKs, serine/threonine kinases that play an important role in cell cycle regulation, are overexpressed in various malignancies. Seliciclib primarily inhibits CDK 2, 7, and 9 by competing for the ATP binding sites on these kinases, leading to a disruption of cell cycle progression. In addition, this agent seems to interfere with CDK-mediated phosphorylation of the carboxy-terminal domain of RNA polymerase II, thereby inhibiting RNA polymerase II-dependent transcription. This may lead to the down-regulation of anti-apoptotic factors, such as myeloid cell leukemia sequence 1 (Mcl-1), a protein crucial for the survival of a range of tumor cell types. The down-regulation of anti-apoptotic factors may lead to an induction of apoptosis, thereby further contributing to seliciclib's antiproliferative effects.NCI
code	C62783
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0462906

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