About: AR Antagonist BMS-641988

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About: AR Antagonist BMS-641988 Goto Sponge NotDistinct Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	AR Antagonist BMS-641988
rdfs:subClassOf	Anti-Androgen nodeID://b648995 nodeID://b648996 nodeID://b648997 nodeID://b648998
Has_Target	Receptors, Androgen
Semantic_Type	Pharmacologic Substance
Preferred_Name	AR Antagonist BMS-641988
UMLS_CUI	C1831892
PDQ_Open_Trial_Search_ID	489385
PDQ_Closed_Trial_Search_ID	489385
Legacy_Concept_Name	BMS-641988
FULL_SYN	AR Antagonist BMS-641988PTNCI BMS-641988CNNCI
DEFINITION	An androgen receptor (AR) antagonist with potential antineoplastic and anti-androgenic activities. BMS-641988 binds to the androgen receptor in target tissues, thereby preventing androgen-induced receptor activation, and facilitates the formation of inactive complexes that cannot be translocated to the nucleus. This may inhibit androgen-dependent gene expression, subsequently leading to an inhibition of cell growth and apoptosis in AR-expressing cells.NCI
code	C62522
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0538957

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