About: Androgen Receptor     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Androgen Receptor
equivalentClass
OMIM_Number
  • 313700
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Receptor
Preferred_Name
  • Androgen Receptor
UMLS_CUI
  • C0034786
Legacy_Concept_Name
  • Androgen_Receptor
FULL_SYN
  • ARABNCI
  • Nuclear Receptor Subfamily 3 Group C Member 4SYNCI
  • DHTRABNCI
  • NR3C4ABNCI
  • Androgen ReceptorPTNCI
  • Dihydrotestosterone ReceptorSYNCI
Swiss_Prot
  • P10275
DEFINITION
  • Androgen receptor (919 aa, ~99 kDa) is encoded by the human AR gene. This protein plays a role in the modulation of steroid-dependent gene transcription.NCI
DesignNote
  • AR has 3 domains: N-terminal modulating (exon 1), DNA-binding (two C4 Zinc fingers, exons 2-3), and C-terminal hormone-binding (5 remaining exons). Polymorphic N-terminal poly-Gln tracts bind RAN, enhancing transactivation; decreased with increased poly-Gln length. An 87-kD (AR-A) isoform lacks a normal N-terminus, seen in the 110 kD (AR-B) form; A and B may differ in function. Ligand bound receptor translocates to the nucleus, homodimerizes, binds DNA, and stimulates transcription.
code
  • C17063
sameAs
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