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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Bafetinib
rdfs:subClassOf
Has_Target
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Bafetinib
UMLS_CUI
  • C2607225
CAS_Registry
  • 859212-16-1
FDA_UNII_Code
  • NVW4Z03I9B
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 500041
PDQ_Closed_Trial_Search_ID
  • 500041
Chemical_Formula
  • C30H31F3N8O
Legacy_Concept_Name
  • INNO-406
FULL_SYN
  • CNS-9CNNCI
  • NS-187CNNCI
  • BAFETINIBPTFDANVW4Z03I9B
  • Benzamide, N-[3-([4,5'-bipyrimidin]-2-ylamino)-4-methylphenyl]-4-[[(3S)-3- (dimethylamino)-1-pyrrolidinyl]methyl]-3-(trifluoromethyl)-SNNCI
  • INNO-406CNNCI
  • Dual Bcr-Abl/Lyn Tyrosine Kinase Inhibitor INNO-406SYNCI
  • BafetinibPTNCI
DEFINITION
  • An orally active 2-phenylaminopyrimidine derivative with potential antineoplastic activity. INNO-406 specifically binds to and inhibits the Bcr/Abl fusion protein tyrosine kinase, an abnormal enzyme produced by Philadelphia chromosomal translocation associated with chronic myeloid leukemia (CML). Furthermore, this agent also inhibits the Src-family member Lyn tyrosine kinase, upregulated in imatinib-resistant CML cells and in a variety of solid cancer cell types. The inhibitory effect of INNO-406 on these specific tyrosine kinases decreases cellular proliferation and induces apoptosis. A high percentage of CML patients are refractory to imatinib, which sometimes results from point mutations occurring in the kinase domain of the Bcr/Abl fusion product. Due to its dual inhibitory activity, INNO-406 has been shown to overcome this particular drug resistance and to be a potent and effective agent in the treatment of imatinib-resistant CML.NCI
code
  • C62516
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