About: Amphotericin B Deoxycholate     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Amphotericin B Deoxycholate
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Semantic_Type
  • Antibiotic
  • Carbohydrate
Preferred_Name
  • Amphotericin B Deoxycholate
UMLS_CUI
  • C0051761
CAS_Registry
  • 58501-21-6
PDQ_Open_Trial_Search_ID
  • 39143
PDQ_Closed_Trial_Search_ID
  • 39143
Legacy_Concept_Name
  • Amphotericin_B_Deoxycholate
FULL_SYN
  • Amphotericin B DeoxycholatePTNCI
  • Amphotericin B-deoxycholateSYNCI
  • FungizoneSYDTPNSC0527017
  • FungizoneBRNCI
DEFINITION
  • The deoxycholate salt of amphotericin B, a polyene antifungal antibiotic produced by Streptomyces nodosus, with antifungal activity. Amphotericin B binds to ergosterol, an essential component of the fungal cell membrane. This results in depolarization of the cell membrane, alterations in cell membrane permeability, leakage of important intracellular components, and cell rupture. This agent may also induce oxidative damage in fungal cells and has been reported to stimulate host immune cells.NCI
code
  • C62201
http://linked.open...y/mesh/hasConcept
is Has_Salt_Form of
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