About: Amphotericin B

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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Amphotericin B
rdfs:subClassOf	ANTIFUNGALS
Has_Salt_Form	Amphotericin B Deoxycholate
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Antibiotic Carbohydrate
Preferred_Name	Amphotericin B
NSC_Code	527017
UMLS_CUI	C0002679
CAS_Registry	1397-89-3
FDA_UNII_Code	7XU7A7DROE
Contributing_Source	FDA
ALT_DEFINITION	A drug used in the treatment of infections caused by fungi. It is a type of antifungal.NCI-GLOSS
Chemical_Formula	C47H73NO17
Legacy_Concept_Name	Amphotercin_B
CHEBI_ID	CHEBI:2682
FULL_SYN	AMPHOTERICIN BPTFDA7XU7A7DROE Amphotericin BPTNCI AmBABNCI Amphotericin bSYDTPNSC0527017 amphotericin BPTNCI-GLOSSCDR0000045173 Amphotericin BPTDCP30128 AmphocilBRNCI AmphotecBRNCI
DEFINITION	A polyene antifungal antibiotic produced by Streptomyces nodosus, with antifungal activity. Amphotericin B binds to ergosterol, an essential component of the fungal cell membrane, thereby causing depolarization of the membrane and altering cell membrane permeability. This leads to leakage of important intracellular components, cell rupture, and eventually cell death. This agent may also induce oxidative damage in fungal cells and has been reported to stimulate host immune cells.NCI
code	C238
sameAs	AMPHOTERICIN B AMPHOTERICIN B
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0001021
is someValuesFrom of	nodeID://b645471 nodeID://b645474
is Has_Free_Acid_Or_Base_Form of	Amphotericin B Deoxycholate
is sameAs of	AMPHOTERICIN B AMPHOTERICIN B AMPHOTERICIN B

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