About: Rosiglitazone     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Rosiglitazone
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Rosiglitazone
UMLS_CUI
  • C0289313
CAS_Registry
  • 122320-73-4
FDA_UNII_Code
  • 05V02F2KDG
Contributing_Source
  • FDA
ALT_DEFINITION
  • The active ingredient in a drug that helps control the amount of glucose (sugar) in the blood and is being studied in the prevention and treatment of some types of cancer. Rosiglitazone stops cells from growing and may prevent the growth of new blood vessels that tumors need to grow. It is a type of thiazolidinedione and a type of antiangiogenesis agent.NCI-GLOSS
Chemical_Formula
  • C18H19N3O3S
Legacy_Concept_Name
  • Rosiglitazone_Base
CHEBI_ID
  • CHEBI:50122
FULL_SYN
  • ROSIGLITAZONEPTFDA05V02F2KDG
  • RosiglitazonePTNCI
  • rosiglitazonePTNCI-GLOSSCDR0000044856
DEFINITION
  • An agent belonging to the glitazone class of antidiabetic agents with antihyperglycemic and anti-inflammatory activities. In addition to its selective affinity for peroxisome proliferator-activated receptor (PPAR) gamma and its ability to lower blood glucose levels, rosiglitazone also exerts anti-inflammatory activity through its ability to inhibit nuclear factor-kappaB (NF-KB) activity and increase I-kappaB levels. In addition, rosiglitazone may cause fluid retention and may worsen congestive heart failure. This agent is also associated with an increased risk of heart attacks.NCI
code
  • C62076
sameAs
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