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AttributesValues
rdf:type
rdfs:label
  • Rosiglitazone Maleate
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Rosiglitazone Maleate
NSC_Code
  • 717764
UMLS_CUI
  • C0795660
CAS_Registry
  • 155141-29-0
Accepted_Therapeutic_Use_For
  • Type 2 diabetes
  • Non-Insulin-Dependent Diabetes Mellitus and Type II Diabetes Mellitus
In_Clinical_Trial_For
  • Liposarcoma.
FDA_UNII_Code
  • KX2339DP44
Contributing_Source
  • FDA
ALT_DEFINITION
  • A drug that helps control the amount of glucose (sugar) in the blood and is being studied in the prevention and treatment of some types of cancer. Avandia stops cells from growing and may prevent the growth of new blood vessels that tumors need to grow. It is a type of thiazolidinedione and a type of antiangiogenesis agent.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 37793
PDQ_Closed_Trial_Search_ID
  • 37793
Chemical_Formula
  • C18H19N3O3S.C4H4O4
Legacy_Concept_Name
  • Rosiglitazone
CHEBI_ID
  • CHEBI:8892
FULL_SYN
  • ROSIGLITAZONE MALEATEPTFDAKX2339DP44
  • (+/-)-5-[[4-[2-(Methyl-2-pyridinylamino)ethoxy]phenyl]methyl]-2,4-thiazolidinedione, ( Z )-2-Butenedioate (1:1)SNNCI
  • AvandiaSYDTPNSC0717764
  • AvandiaPTNCI-GLOSSCDR0000601484
  • rosiglitazone maleatePTNCI-GLOSSCDR0000601483
  • Rosiglitazone MaleatePTDCP20342
  • AvandiaBRNCI
  • BRL49653CNNCI
  • Rosiglitazone MaleatePTNCI
DEFINITION
  • The maleate salt of rosiglitazone, an orally-active thiazolidinedione with antidiabetic properties and potential antineoplastic activity. Rosiglitazone activates peroxisome proliferator-activated receptor gamma (PPAR-gamma), a ligand-activated transcription factor, thereby inducing cell differentiation and inhibiting cell growth and angiogenesis. This agent also modulates the transcription of insulin-responsive genes, inhibits macrophage and monocyte activation, and stimulates adipocyte differentiation.NCI
code
  • C2583
sameAs
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