About: Pravastatin     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Pravastatin
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Pravastatin
UMLS_CUI
  • C0085542
CAS_Registry
  • 81093-37-0
FDA_UNII_Code
  • KXO2KT9N0G
Contributing_Source
  • FDA
ALT_DEFINITION
  • The active ingredient in a drug used to lower the amount of cholesterol in the blood and to prevent stroke and heart attack. It is also being studied in the treatment of cancer and other conditions. Pravastatin blocks an enzyme that helps make cholesterol in the body. It may also make tumor cells more sensitive to anticancer drugs. It is a type of HMG-CoA reductase inhibitor, a type of statin, and a type of chemosensitizer.NCI-GLOSS
Chemical_Formula
  • C23H36O7
Legacy_Concept_Name
  • Pravastatin_Base
CHEBI_ID
  • CHEBI:63618
FULL_SYN
  • PravastatinPTNCI
  • pravastatinPTNCI-GLOSSCDR0000430875
  • [1S-[1alpha(betaS*,deltaS*),2alpha,6alpha,8beta(R*),8aalpha]]-1,2,6,7,8,8a-Hexahydro-beta,!d,6-trihydroxy-2-methyl-8-(2-methyl-1-oxobutoxy)-1-naphthaleneheptanoic AcidPTDCP02539
  • PRAVASTATINPTFDAKXO2KT9N0G
DEFINITION
  • A synthetic lipid-lowering agent. Pravastatin competitively inhibits hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, the enzyme which catalyzes the conversion of HMG-CoA to mevalonate, a key step in cholesterol synthesis. Pravastatin lowers plasma cholesterol and lipoprotein levels, and modulates immune responses by suppressing MHC II (major histocompatibility complex II) on interferon gamma-stimulated, antigen-presenting cells such as human vascular endothelial cells. (NCI04)NCI
code
  • C62070
sameAs
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