About: Pravastatin Sodium     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Pravastatin Sodium
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Pravastatin Sodium
UMLS_CUI
  • C0700763
CAS_Registry
  • 81131-70-6
FDA_UNII_Code
  • 3M8608UQ61
Contributing_Source
  • FDA
ALT_DEFINITION
  • A drug used to lower the amount of cholesterol in the blood and to prevent stroke and heart attack. It is also being studied in the treatment of cancer and other conditions. Pravastatin sodium blocks an enzyme that helps make cholesterol in the body. It may also make tumor cells more sensitive to anticancer drugs. It is a type of HMG-CoA reductase inhibitor, a type of statin, and a type of chemosensitizer.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 424450
PDQ_Closed_Trial_Search_ID
  • 424450
Chemical_Formula
  • C23H35O7.Na
Legacy_Concept_Name
  • Pravastatin
CHEBI_ID
  • CHEBI:8361
FULL_SYN
  • pravastatin sodiumPTNCI-GLOSSCDR0000618548
  • Pravastatin SodiumPTDCP20414
  • Pravastatin SodiumPTNCI
  • PRAVASTATIN SODIUMPTFDA3M8608UQ61
DEFINITION
  • The sodium salt of pravastatin with cholesterol-lowering and potential antineoplastic activities. Pravastatin competitively inhibits hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, the enzyme which catalyzes the conversion of HMG-CoA to mevalonate, a key step in cholesterol synthesis. This agent lowers plasma cholesterol and lipoprotein levels, and modulates immune responses by suppressing MHC II (major histocompatibility complex II) on interferon gamma-stimulated, antigen-presenting cells such as human vascular endothelial cells. In addition, pravastatin, like other statins, exhibits pro-apoptotic, growth inhibitory, and pro-differentiation activities in a variety of tumor cells; these antineoplastic activities may be due, in part, to inhibition of the isoprenylation of Ras and Rho GTPases and related signaling cascades.NCI
code
  • C29375
sameAs
http://linked.open...y/mesh/hasConcept
is Has_Salt_Form of
is sameAs of
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