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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Imatinib
rdfs:subClassOf
Has_Salt_Form
Has_Target
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Imatinib
UMLS_CUI
  • C0935989
CAS_Registry
  • 152459-95-5
FDA_UNII_Code
  • BKJ8M8G5HI
Contributing_Source
  • FDA
Chemical_Formula
  • C29H31N7O
Legacy_Concept_Name
  • Imatinib_Base
CHEBI_ID
  • CHEBI:45783
FULL_SYN
  • 4-[(4-Methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]benzamideSNNCI
  • IMATINIBPTFDABKJ8M8G5HI
  • ImatinibPTNCI
DEFINITION
  • An antineoplastic agent that inhibits the Bcr-Abl fusion protein tyrosine kinase, an abnormal enzyme produced by chronic myeloid leukemia cells that contain the Philadelphia chromosome. Imatinib also inhibits the receptor tyrosine kinases for platelet-derived growth factor (PDGF) and stem cell factor (SCF)/c-kit; the SCF/c-kit receptor tyrosine kinase is activated in gastrointestinal stromal tumor (GIST). This agent inhibits proliferation and induces apoptosis in cells that overexpress these oncoproteins.NCI
code
  • C62035
sameAs
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