About: Hydromorphone     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Hydromorphone
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Hydromorphone
UMLS_CUI
  • C0012306
CAS_Registry
  • 466-99-9
FDA_UNII_Code
  • Q812464R06
Contributing_Source
  • FDA
ALT_DEFINITION
  • A drug used to relieve pain.NCI-GLOSS
Chemical_Formula
  • C17H19NO3
Legacy_Concept_Name
  • Hydromorphone_Base
CHEBI_ID
  • CHEBI:5790
FULL_SYN
  • HYDROMORPHONEPTFDAQ812464R06
  • HydromorphonSYDTPNSC0019046
  • HydromorphonSYNCI
  • HydromorphonePTNCI
  • HydromorphoneSYDTPNSC0019046
  • hydromorphonePTNCI-GLOSSCDR0000045217
  • DihydromorphinoneSYNCI
  • (-)-HydromorphoneSYDTPNSC0019046
  • DihydromorphinoneSYDTPNSC0019046
DEFINITION
  • The hydrogenated ketone of morphine, a semi-synthetic opioid with analgesic effects. Hydromorphone selectively binds the mu-opioid receptor which is linked through G-proteins. Binding stimulates the exchange of guanosine triphosphate (GTP) for guanosine diphosphate (GDP) on the G-protein complex and interacts with and inhibits adenylate cyclase located at the inner surface of the plasma membrane. This leads to a reduction in intracellular cyclic 3',5'-adenosine monophosphate (cAMP). Further, voltage-gated potassium channels are activated, thereby causing hyperpolarization and reducing neuronal excitability. In addition, the opening of voltage-gated calcium channels is inhibited, thereby leading to an inhibition of calcium entry and a reduction in the release of various neurotransmitters, including GABA, vasopressin, somatostatin, insulin and glucagons.NCI
code
  • C62034
sameAs
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