About: Hydromorphone Hydrochloride

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About: Hydromorphone Hydrochloride Goto Sponge NotDistinct Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Hydromorphone Hydrochloride
rdfs:subClassOf	Opioid Opioid Agonist
Has_Free_Acid_Or_Base_Form	HYDROMORPHONE
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Organic Chemical Pharmacologic Substance
Preferred_Name	Hydromorphone Hydrochloride
NSC_Code	19046
UMLS_CUI	C0700533
CAS_Registry	71-68-1
Accepted_Therapeutic_Use_For	pain in opioid-tolerant patients.
FDA_UNII_Code	L960UP2KRW
Contributing_Source	FDA
ALT_DEFINITION	An opioid analgesic made from MORPHINE and used mainly as an analgesic. It has a shorter duration of action than morphine.MSH2002_06_01
PDQ_Open_Trial_Search_ID	574280
PDQ_Closed_Trial_Search_ID	574280
Chemical_Formula	C17H19NO3.HCl
Legacy_Concept_Name	Hydromorphone
CHEBI_ID	CHEBI:5791
FULL_SYN	Dilaudid HPBRNCI Hydromorphone HydrochloridePTNCI DilaudidSYDTPNSC0117862 LaudiconSYDTPNSC0019046 ExalgoBRNCI DilaudidBRNCI LaudiconBRNCI HymorphanBRNCI HydrostatBRNCI HYDROMORPHONE HYDROCHLORIDEPTFDAL960UP2KRW DimorphoneBRNCI NovolaudenBRNCI
DEFINITION	The hydrochloride salt form of hydromorphone, the hydrogenated ketone of morphine, a semi-synthetic opioid with analgesic effects. Hydromorphone selectively binds the mu-opioid receptor which is linked through G-proteins. Binding stimulates the exchange of guanosine triphosphate (GTP) for guanosine diphosphate (GDP) on the G-protein complex and interacts with and inhibits adenylate cyclase located at the inner surface of the plasma membrane. This leads to a reduction in intracellular cyclic 3',5'-adenosine monophosphate (cAMP). Further, voltage-gated potassium channels are activated, thereby causing hyperpolarization and reducing neuronal excitability. In addition, the opening of voltage-gated calcium channels is inhibited, thereby leading to an inhibition of calcium entry and a reduction in the release of various neurotransmitters, including GABA, vasopressin, somatostatin, insulin and glucagons.NCI
code	C436
sameAs	HYDROMORPHONE HYDROCHLORIDE HYDROMORPHONE HYDROCHLORIDE
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0352944
is Has_Salt_Form of	HYDROMORPHONE
is sameAs of	HYDROMORPHONE HYDROCHLORIDE HYDROMORPHONE HYDROCHLORIDE HYDROMORPHONE HYDROCHLORIDE

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